Trofame Xr 60mg Cap 10sDrug brand named TROFAME XR 60MG CAP 10S is manufactured by Sun Pharmaceuticals Industries Ltd and mainly contents the generic drug Trospium Chloride.
Active Ingredients of TROFAME XR 60MG CAP 10STrospium Chloride 60 mg
Can we use TROFAME XR 60MG CAP 10S during pregnencyPregnancy D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans but potential benefits may warrant use of the drug in pregnant women despite potential risks
Can we use TROFAME XR 60MG CAP 10S during lactationLactation L4 There is positive evidence of risk to a breastfed infant or to breastmilk production but the benefits of use in breastfeeding mothers may be acceptable despite the risk to the infant eg if the drug is needed in a lifethreatening situation or for a serious disease for which safer drugs cannot be used or are ineffective
For what type of diseases TROFAME XR 60MG CAP 10S may be prescribedOver active bladder
What are the known Side Effects of TROFAME XR 60MG CAP 10SNausea stomach upset skin rash acute toxicity
Precautions before taking TROFAME XR 60MG CAP 10SDigoxin Concomitant use of 20 mg SANCTURA trospium chloride immediate release twice daily at steady state and a single dose of 05 mg digoxin in a crossover study with 40 male and female subjects did not affect the pharmacokinetics of either drug Antacid A study was conducted to evaluate the effect of an antacid containing aluminum hydroxide and magnesium carbonate on the pharmacokinetics of SANCTURA XR nl 1 While the systemic exposure of trospium on average was comparable with and without antacid 5 individuals demonstrated either an increase or decrease in trospium exposure in presence of antacid Metformin A study was conducted in which SANCTURA XR 60 mg once daily was coadministered with Glucophage metformin hydrochloride 500 mg twice daily under steadystate conditions in 44 healthy subjects Coadministration of 500 mg metformin immediate release tablets twice daily reduced the steadystate systemic exposure of trospiumby approximately 29 for mean AUC024 and by 34 for mean Cmax The effect of decrease in trospium exposure on the efficacy of SANCTURA XR is unknownThe steadystate pharmacokinetics of metformin were comparable when administered with or without 60 mg SANCTURA XR once daily under fasted condition The effect of metformin at higher doses on trospium PK is unknown
Significance of TROFAME XR 60MG CAP 10STrospium chloride is an antispasmodic antimuscarinic agent Trospium chloride antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs including the bladder Its parasympatholytic action reduces the tonus of smooth muscle in the bladder